Arbman G, Nilsson E, Störgren-Fordell V, Sjödahl R
Department of Surgery, Central Hospital, Norrköping, Sweden.
Eur J Surg. 1996 Nov;162(11):899-904.
To study the association between a short diagnostic delay and tumour stage in patients with colonic and rectal cancer.
Prospective study.
Multicentre study, Sweden.
336 patients with colonic, and 218 patients with rectal cancer.
Incidence and duration of symptoms, delay in diagnosis, and stage at diagnosis.
Patients with rectal cancer and a delay of less than a month between start of symptoms and diagnosis included a significantly larger proportion of Dukes' A tumours than patients with a longer delay (p = 0.004). Delay in patients with colonic cancer did not correlate with stage.
A short delay in the diagnosis of rectal cancer was associated with better staging. This could not be shown for colonic cancer, which may be attributable to its initially vague symptoms and to a subgroup of highly malignant tumours with rapidly progressive symptoms.
研究结肠癌和直肠癌患者诊断延迟时间短与肿瘤分期之间的关联。
前瞻性研究。
瑞典多中心研究。
336例结肠癌患者和218例直肠癌患者。
症状的发生率和持续时间、诊断延迟以及诊断时的分期。
直肠癌患者中,症状开始至诊断时间间隔少于1个月的患者,其Dukes'A期肿瘤的比例显著高于延迟时间较长的患者(p = 0.004)。结肠癌患者的诊断延迟与分期无关。
直肠癌诊断延迟时间短与更好的分期相关。结肠癌未显示出这种关联,这可能归因于其最初模糊的症状以及一小部分具有快速进展症状的高恶性肿瘤。