Kawasaki N, Matsuo Y, Yoshino T, Yanai H, Oka T, Teramoto N, Liu C, Kondo E, Minowada J, Akagi T
Department of Pathology, Okayama University Medical School, Shikata-cho, Japan.
Jpn J Cancer Res. 1996 Oct;87(10):1070-7. doi: 10.1111/j.1349-7006.1996.tb03112.x.
To investigate whether the lymphocyte homing receptors, adhesion molecules regulating normal lymphocyte traffic, influence the dissemination of lymphoma cells, 24 lymphoma/leukemia cell lines were inoculated into SCID mice subcutaneously, and the correlation between the expression of the adhesion molecules and the metastatic potential of the cell lines was examined. Among the six adhesion molecules examined (LFA-1, ICAM-1, CLA, VLA-4, L-selectin and CD44), L-selectin increased the incidence of lymph node metastasis, and CD44 expression was related to both lymph node and organ (hematogenous) metastasis. A monoclonal antibody to the standard form of CD44 (CD44s), Hermes-3, inhibited the local growth and remote metastasis of CD44+ cell lines. Thus, it is concluded that at least CD44s expression is important in both lymphatic and hematogenous metastasis.
为研究淋巴细胞归巢受体（调节正常淋巴细胞运输的黏附分子）是否影响淋巴瘤细胞的播散，将24种淋巴瘤/白血病细胞系皮下接种到SCID小鼠体内，检测黏附分子表达与细胞系转移潜能之间的相关性。在所检测的6种黏附分子（淋巴细胞功能相关抗原-1、细胞间黏附分子-1、皮肤淋巴细胞相关抗原、迟现抗原-4、淋巴细胞选择素和CD44）中，淋巴细胞选择素增加了淋巴结转移的发生率，CD44表达与淋巴结转移及器官（血行性）转移均相关。针对标准形式CD44（CD44s）的单克隆抗体Hermes-3可抑制CD44+细胞系的局部生长和远处转移。因此，得出结论：至少CD44s表达在淋巴转移和血行转移中均很重要。
