Knight T E, Boll P, Epstein W L, Prasad A K
Division of Dermatology, University of Hawaii School of Medicine, Honolulu, HI, USA.
Am J Contact Dermat. 1996 Sep;7(3):138-45.
All allergic contact dermatitis caused by Philodendron species is common in the Hawaiian islands, and Toxicodendron species are the most common causes of plant-induced allergic contact dermatitis in North America.
The purpose of this study was to determine the incidence of cross-sensitivity between these plant species.
Alkylresorcinols (pentadec[en]yl and heptadec[en]ylresorcinols) were isolated and purified from extracts of Hawaiian-grown Philodendron scandens subspecies scandens and Philodendron lacerum. Alkylcatechols (mixtures of pentadec[en]ylcatechols from an extract of Toxicodendron radicans (poison ivy) were obtained from the Division of Biologics Standards (National Institutes of Health, Bethesda, MD). Seventeen patients from Hawaii and 8 patients from northern California were skin tested with 5 microL (concentrations, 1 to .001 mg/mL) of each allergen applied to the flexor forearm. The test sites remained open and were graded at 72, 96, and 144 hours. All 8 patients from California were naive to Philodendron species, and 8 patients from Hawaii were naive to Toxicodendron species.
No cross-reactivity occurred in patients who were Philodendron sensitive and Toxicodendron naive when tested to the homologous Toxicodendron catechols. Conversely, with one exception, no cross-reactivity occurred in patients who were Toxicodendron sensitive and Philodendron naive when tested to homologous Philodendron naive when tested to homologous Philodendron resorcinols.
Patients who are sensitive to Philodendron species (or other resorcinol-containing plants) may not necessarily be cross-sensitive to Toxicodendron species and vice versa.
由喜林芋属植物引起的所有过敏性接触性皮炎在夏威夷群岛很常见，而毒漆藤属植物是北美植物引起的过敏性接触性皮炎最常见的原因。
本研究的目的是确定这些植物物种之间交叉敏感性的发生率。
从夏威夷种植的攀援喜林芋亚种和撕裂喜林芋的提取物中分离并纯化烷基间苯二酚（十五[烯]基和十七[烯]基间苯二酚）。从生物制品标准司（美国国立卫生研究院，马里兰州贝塞斯达）获得来自毒漆藤（毒葛）提取物的烷基儿茶酚（十五[烯]基儿茶酚混合物）。来自夏威夷的17名患者和来自加利福尼亚北部的8名患者在前臂屈侧用5微升（浓度为1至0.001毫克/毫升）的每种变应原进行皮肤试验。试验部位保持开放，并在72、96和144小时进行分级。所有8名来自加利福尼亚的患者未曾接触过喜林芋属植物，8名来自夏威夷的患者未曾接触过毒漆藤属植物。
对喜林芋敏感且未曾接触过毒漆藤的患者在测试同源毒漆藤儿茶酚时未发生交叉反应。相反，除了一个例外，对毒漆藤敏感且未曾接触过喜林芋的患者在测试同源喜林芋间苯二酚时未发生交叉反应。
对喜林芋属植物（或其他含间苯二酚的植物）敏感的患者不一定对毒漆藤属植物交叉敏感，反之亦然。
