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支气管源性肺癌肺切除术后残肺的癌切除术

Cancer resection on the residual lung after pneumonectomy for bronchogenic carcinoma.

作者信息

Spaggiari L, Grunenwald D, Girard P, Baldeyrou P, Filaire M, Dennewald G, Saint-Maurice O, Tric L

机构信息

Department of Thoracic Surgery, Institut Mutualiste Montsouris, Paris, France.

出版信息

Ann Thorac Surg. 1996 Dec;62(6):1598-602. doi: 10.1016/s0003-4975(96)00608-x.

Abstract

BACKGROUND

After pneumonectomy for bronchogenic carcinoma, the residual lung may be the site of a new lung cancer or metastatic spread.

METHODS

From 1989 to 1995, 13 patients with carcinoma on the residual lung after pneumonectomy for lung cancer were operated on. Three segmentectomies and 7 simple wedge resections were performed, 2 patients had multiple wedge resections, and 1 patient had an exploratory thoracotomy. Nine patients had a primary metachronous bronchogenic carcinoma, 3 had metastases from bronchogenic carcinoma, and no definite conclusion was reached in 1 case.

RESULTS

No postoperative mortality was observed. Four patients had postoperative complications. The mean postoperative hospital stay was 14 days. Seven patients are alive, including 5 patients without evidence of disease. Six patients died of their disease, all with pulmonary recurrences. The overall median survival was 19 months, with a probability of survival at 3 years (Kaplan-Meier) of 46% (95% confidence interval, 22% to 73%).

CONCLUSIONS

Limited pulmonary resection for lung cancer after pneumonectomy for bronchogenic carcinoma is feasible with very low morbidity. In highly selected patients, surgical resection might prolong survival.

摘要

背景

在因支气管源性肺癌行肺切除术后,残余肺可能成为新发肺癌或转移扩散的部位。

方法

1989年至1995年,对13例因肺癌行肺切除术后残余肺发生癌的患者进行了手术。其中3例行肺段切除术,7例行单纯楔形切除术,2例患者行多次楔形切除术,1例患者行剖胸探查术。9例为原发性异时性支气管源性肺癌,3例为支气管源性癌转移,1例未得出明确结论。

结果

未观察到术后死亡病例。4例患者出现术后并发症。术后平均住院时间为14天。7例患者存活,其中5例无疾病证据。6例患者死于疾病,均为肺部复发。总体中位生存期为19个月,3年生存率(Kaplan-Meier法)为46%(95%置信区间,22%至73%)。

结论

因支气管源性肺癌行肺切除术后,对残余肺的肺癌进行有限的肺切除术是可行的,发病率极低。在经过严格挑选的患者中,手术切除可能会延长生存期。

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