Freerksen E, Kanthunkumva E W, Kholowa A R
St. Gabriel's Hospital, Namitete, Malawi.
Chemotherapy. 1996 Nov-Dec;42(6):391-401. doi: 10.1159/000239472.
Following the brief information on a new malaria treatment with the fixed multiple combination Cotrifazid (rifampicin+isoniazid+sulfamethoxazole+trimethoprim) in Chemotherapy [1995;41:396-398], very good results are reported for the treatment of 61 patients with various forms of malaria. The tolerance was found to be good. Some relevant fundamental considerations (chemoresistance, synergism/antagonism, fixed multiple combination, switching from monotherapy to combination therapy) and the implementation of the principle of a "multidisease therapy' are discussed.
继《化疗》杂志[1995年；41卷：396 - 398页]上一篇关于用固定复方科特里法齐德（利福平+异烟肼+磺胺甲恶唑+甲氧苄啶）治疗疟疾的简短信息之后，有报道称在治疗61例各种类型疟疾患者方面取得了非常好的效果。发现耐受性良好。文中讨论了一些相关的基本考虑因素（化学抗性、协同作用/拮抗作用、固定复方、从单一疗法转换为联合疗法）以及“多病同治”原则的实施情况。
