Nishioka K, Murata M, Ishikawa T, Kaniwa M
Department of Dermatology, Yamaguchi Red Cross Hospital, Japan.
Contact Dermatitis. 1996 Oct;35(4):241-5. doi: 10.1111/j.1600-0536.1996.tb02366.x.
An investigation was conducted as follows in 9 farmers with contact allergy due to rubber boots: (i) patch tests with 19 rubber additives; (ii) chemical analysis of additives in 6 pairs of rubber boots; (iii) use tests on a hypoallergenic trial product in 5 patients. The following results were obtained: (i) in the patch tests, all 9 patients showed positive reactions to 1 or more of the nitrogen(N)-containing antioxidants (IPPD, DMBPPD, ETMDQ); (ii) ETMDQ was detected in 1 pair of rubber boots, and IPPD and DMBPPD in another pair; (iii) no patient using hypoallergenic boots during rice-planting had recurrent dermatitis. N-containing antioxidants, such as IPPD, DMBPPD and ETMDQ, were thus considered as the main causative agents and the trial product was found useful for managing contact dermatitis. Contact allergy due to ETMDQ in rubber is reported here for the 1st time.
对9名因橡胶靴导致接触性过敏的农民进行了如下调查：(i) 用19种橡胶添加剂进行斑贴试验；(ii) 对6双橡胶靴中的添加剂进行化学分析；(iii) 对5名患者使用低敏试验产品进行使用测试。得到以下结果：(i) 在斑贴试验中，所有9名患者对1种或更多含氮（N）抗氧化剂（IPPD、DMBPPD、ETMDQ）呈阳性反应；(ii) 在1双橡胶靴中检测到ETMDQ，在另一双中检测到IPPD和DMBPPD；(iii) 在水稻种植期间使用低敏靴的患者均无复发性皮炎。因此，含氮抗氧化剂，如IPPD、DMBPPD和ETMDQ，被认为是主要致病因素，并且发现该试验产品对治疗接触性皮炎有用。本文首次报道了橡胶中ETMDQ引起的接触性过敏。
