美罗培南对耐环丙沙星肠杆菌科细菌和铜绿假单胞菌的体外活性。
In vitro activity of meropenem against ciprofloxacin-resistant enterobacteriaceae and Pseudomonas aeruginosa.
作者信息
Garcia-Rodriguez J A, Blazquez A M, Fresnadillo M J, Garcia Sanchez E, Garcia Sanchez J E, Trujillano Martin I
机构信息
Department of Microbiology and Parasitology, Hospital Universitario, Facultad de Medicina, Salamanca, Spain.
出版信息
J Chemother. 1996 Oct;8(5):358-64. doi: 10.1179/joc.1996.8.5.358.
The in-vitro susceptibilities of a total of 174 ciprofloxacin-resistant Enterobacteriaceae and Pseudomonas aeruginosa were determined. According to the BSAC and NCCLS breakpoints, meropenem, aztreonam, ceftibuten, ceftazidime, imipenem and cefotaxime were the most active (> 90%) antimicrobial agents tested against Enterobacteriaceae. Susceptibility of these strains to piperacillin/tazobactam, cefpodoxime and cefixime (84.96%) was higher than that to tobramycin, gentamicin and fosfomycin (50-75%). More than 90% of P. aeruginosa were susceptible to meropenem when both interpretative susceptibility breakpoint criteria were used. Piperacillin, piperacillin/tazobactam and ceftazidime were active against 50-75% of the same strains. Meropenem was the most active antimicrobial tested against all ciprofloxacin-resistant clinical isolates assayed.
测定了总共174株耐环丙沙星的肠杆菌科细菌和铜绿假单胞菌的体外药敏情况。根据英国抗菌化疗学会（BSAC）和美国国家临床实验室标准委员会（NCCLS）的折点标准，美罗培南、氨曲南、头孢布烯、头孢他啶、亚胺培南和头孢噻肟是针对肠杆菌科细菌检测出的活性最高（>90%）的抗菌药物。这些菌株对哌拉西林/他唑巴坦（84.96%）、头孢泊肟和头孢克肟的敏感性高于对妥布霉素、庆大霉素和磷霉素（50 - 75%）的敏感性。当使用两种解释性药敏折点标准时，超过90%的铜绿假单胞菌对美罗培南敏感。哌拉西林、哌拉西林/他唑巴坦和头孢他啶对50 - 75%的相同菌株有活性。美罗培南是针对所有检测的耐环丙沙星临床分离株检测出的活性最高的抗菌药物。
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