Buritova J, Fletcher D, Honoré P, Besson J M
Unité de Recherches de Physiopharmacologie du Système Nerveux, INSERM U161, Paris, France.
Br J Anaesth. 1996 Nov;77(5):645-52. doi: 10.1093/bja/77.5.645.
We have assessed the effects of intraplantar local anaesthetics (bupivacaine and lignocaine) on carrageenan-induced oedema, mechanical allodynia and spinal c-fos protein expression. Mechanical allodynia was evaluated using the vocalization threshold to paw pressure (VTPP) every 30 min until 60, 180 or 240 min after administration of carrageenan. Peripheral oedema, mechanical allodynia and spinal c-fos protein expression were maximal 180 min after carrageenan. Lignocaine did not influence either oedema or VTPP, but reduced spinal c-fos expression at 60 min after carrageenan without later effects. Bupivacaine induced an increase in VTPP at 30 and 60 min, limitation of oedema at 60 min and a reduction in spinal c-fos expression at 60 and 180 min, but these effects were not present 240 min after carrageenan. Intraplantar infiltration with lignocaine and bupivacaine before carrageenan transiently limited signs of inflammatory pain but did not prevent them.
我们评估了足底局部麻醉剂（布比卡因和利多卡因）对角叉菜胶诱导的水肿、机械性异常性疼痛和脊髓c-fos蛋白表达的影响。使用爪部压力发声阈值（VTPP）每30分钟评估一次机械性异常性疼痛，直至在注射角叉菜胶后60、180或240分钟。角叉菜胶注射后180分钟时，外周水肿、机械性异常性疼痛和脊髓c-fos蛋白表达达到最大值。利多卡因对角叉菜胶诱导的水肿和VTPP均无影响，但在角叉菜胶注射后60分钟时可降低脊髓c-fos表达，且无后期效应。布比卡因在30和60分钟时可使VTPP升高，在60分钟时可限制水肿，并在60和180分钟时降低脊髓c-fos表达，但在角叉菜胶注射后240分钟时这些效应消失。在注射角叉菜胶前，用利多卡因和布比卡因进行足底浸润可暂时限制炎性疼痛的体征，但不能预防这些体征。
