鸡的胸腺细胞迁移：外周血中CD4⁺细胞比CD8⁺细胞占比更高。
Thymocyte emigration in the chicken: an over-representation of CD4+ cells over CD8+ in the periphery.
作者信息
Katevuo K, Vainio O
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
Immunology. 1996 Nov;89(3):419-23. doi: 10.1046/j.1365-2567.1996.d01-764.x.
We have examined the emigration of chicken thymocytes after intrathymic fluorescein isothiocyanate (FITC) labelling in situ. In this paper we show that in young birds about 0.7% and 0.4% of thymocytes emigrate from the thymus to the blood and the spleen, respectively, per day. This suggests that, as in mammals, most thymocytes die within the thymus. At 3 weeks of age gamma delta and alpha beta T cells leave the thymus in comparable levels to their appearance in the blood. The phenotype of recent emigrants in peripheral tissues is similar to that of mature T cells. Interestingly, recent emigrants contain relatively much higher numbers of CD4+ and fewer CD8+ cells than is observed in peripheral tissues in a steady-state situation.
我们检测了鸡胸腺细胞在胸腺内原位异硫氰酸荧光素（FITC）标记后的迁出情况。在本文中，我们表明，幼鸟中每天分别约有0.7%和0.4%的胸腺细胞从胸腺迁移至血液和脾脏。这表明，与哺乳动物一样，大多数胸腺细胞在胸腺内死亡。在3周龄时，γδ和αβ T细胞离开胸腺的水平与其在血液中的出现水平相当。外周组织中近期迁出细胞的表型与成熟T细胞相似。有趣的是，与稳态情况下外周组织中观察到的情况相比，近期迁出细胞中CD4+细胞数量相对较多，CD8+细胞数量较少。
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