Rosa N, Cennamo G, Del Prete A, Bianco S, Sebastiani A
Istituto di Oftalmologia Università Federico II, Napoli, Italia.
Ophthalmologica. 1997;211(1):32-9. doi: 10.1159/000310871.
To evaluate long-term corneal endothelium damages after myopic photorefractive keratectomy (PRK) a morphometric analysis of corneal endothelial cells was performed in 41 patients before and at least 24 months after photorefractive keratectomy. These patients underwent a treatment ranging from -2.5 to -14 dpt with a mean of 8.9 +/- 2.8 dpt at the corneal apex, with an estimated corneal thinning ranging from 23 to 123 microns with a mean of 78 +/- 24.4 microns. Our results showed that the density of endothelial cells ranged from 2,334 to 3,554/mm2 with a mean of 2,819 +/- 351/mm2 before surgery, and from 2,051 to 3,461/mm2 with a mean of 2,774 +/- 330/mm2 after surgery without any significant changes (p = 0.16). The polymorphic index ranged from 58 to 84 with a mean of 77 +/- 5.7 before PRK and from 57 to 89 with mean of 77.7 +/- 7.2 after treatment without any significant changes (p = 0.61). In conclusion, we can state that there is no long-term corneal endothelial damage after PRK even in highly myopic eyes.
为评估近视性准分子激光原位角膜磨镶术（PRK）后角膜内皮细胞的长期损伤情况，对41例患者在准分子激光原位角膜磨镶术前及术后至少24个月进行了角膜内皮细胞形态学分析。这些患者的治疗屈光度范围为-2.5至-14 dpt，角膜顶点平均为8.9 +/- 2.8 dpt，估计角膜变薄范围为23至123微米，平均为78 +/- 24.4微米。我们的结果显示，术前内皮细胞密度范围为2334至3554/mm²，平均为2819 +/- 351/mm²，术后为2051至3461/mm²，平均为2774 +/- 330/mm²，无任何显著变化（p = 0.16）。多形性指数在PRK术前范围为58至84，平均为77 +/- 5.7，治疗后为57至89，平均为77.7 +/- 7.2，无任何显著变化（p = 0.61）。总之，我们可以说，即使是高度近视眼中，PRK术后也不存在长期角膜内皮损伤。
