精神分裂症患者纹状体中的蛋白激酶C和腺苷酸环化酶均未发生改变。

Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia.

作者信息

Opeskin K, Dean B, Pavey G, Hill C, Keks N, Copolov D

机构信息

Rebecca L. Cooper Laboratories, Mental Health Research Institute of Victoria, Parkville, Australia.

出版信息

Schizophr Res. 1996 Nov 15;22(2):159-64. doi: 10.1016/s0920-9964(96)00065-5.

DOI:10.1016/s0920-9964(96)00065-5

PMID:8958600

Abstract

Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 +/- 35 vs. 485 +/- 29 fmol/mg tissue equivalents (TE), mean +/- SEM) or AC (77 +/- 9 vs. 80 +/- 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.

摘要

多巴胺（DA）D2受体通过调节包括蛋白激酶C（PKC）和腺苷酸环化酶（AC）在内的第二信使途径发挥作用，反复研究表明，精神分裂症患者纹状体中的D2受体增加。因此，精神分裂症患者大脑中DA - D2受体的慢性上调似乎可能导致这两种蛋白质中的任何一种发生变化。因此，我们通过定量放射自显影法测量了20名精神分裂症患者和20名非精神分裂症患者纹状体中的PKC和AC，结果显示，与非精神分裂症患者相比，精神分裂症患者组织中PKC（436±35对485±29 fmol/mg组织当量（TE），平均值±标准误）或AC（77±9对80±7 fmol/mg TE）的密度均无差异。因此，这些数据不支持精神分裂症患者大脑中PKC或AC发生变化的假说。