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酒精中毒治疗研究中的综合结局指标:问题与潜力

Composite outcome measures in alcoholism treatment research: problems and potentialities.

作者信息

Zweben A, Cisler R

机构信息

Center for Addiction and Behavioral Health Research, School of Social Welfare, University of Wisconsin-Milwaukee 53201-0786, USA.

出版信息

Subst Use Misuse. 1996 Nov;31(13):1783-805. doi: 10.3109/10826089609064001.

Abstract

Alcoholism treatment researchers have increasingly incorporated multiple measures representing multiple dimensions in assessing treatment outcomes. However, no satisfactory model exists for examining the dynamic interrelationships of multiple measures in determining clinically meaningful and interpretable outcomes. One approach to analyzing multiple outcomes is to combine them into a composite measure. In their most elementary form, composite measures combine alcohol consumption and consumption-related problems dimensions into treatment outcome classifications. This paper discusses conceptual and methodological issues in studies reporting composite outcomes and provides a model and recommendations for using composite measures in alcohol treatment research.

摘要

酒精成瘾治疗研究人员在评估治疗结果时越来越多地纳入了代表多个维度的多种测量方法。然而,在确定具有临床意义且可解释的结果时,不存在用于检验多种测量方法动态相互关系的令人满意的模型。分析多种结果的一种方法是将它们组合成一个综合测量指标。在其最基本的形式中,综合测量指标将酒精消费和与消费相关的问题维度纳入治疗结果分类。本文讨论了报告综合结果的研究中的概念和方法问题,并提供了一个模型以及在酒精治疗研究中使用综合测量指标的建议。

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