Matsuo T, Shirakusa T, Kawahara K, Iwasaki A, Okabayashi H, Shiraishi T
Department of Surgery, School of Medicine, Fukuoka University, Japan.
Kyobu Geka. 1996 Dec;49(13):1110-3.
Generally yolk sac tumor in the mediastinum is a rare and highly malignant neoplasm. We report a case of yolk sac tumor, which was treated with resection, and then intraoperative hypotonic and postoperative systemic chemotherapy. A 33-year-old man was diagnosed as a mediastinal tumor with chest X-ray and chest CT findings. At operation he had mediastinal tumor which invaded to the part of the right upper lobe and pericardium, disseminated on the right diaphragm. A large tumor was removed with partial pericardiectomy and wedge resection of the right upper lobe. After resection hypotonic chemotherapy with cis-platinum was performed. This tumor had endodermal sinus structure, Schiller-Duval body, and eosinophilic hyaline globolus which were histological characteristics of yolk sac tumor, and the value of serum alpha-fetoprotein (AFP) was high. After operation with this diagnosis systemic chemotherapy consisted of cis-platinum, etoposide were performed. Patient was discharged uneventfully 8 months later.
纵隔内的卵黄囊瘤通常是一种罕见且高度恶性的肿瘤。我们报告一例卵黄囊瘤病例，该病例接受了手术切除，随后进行了术中低渗化疗和术后全身化疗。一名33岁男性经胸部X线和胸部CT检查被诊断为纵隔肿瘤。手术时，他患有纵隔肿瘤，侵犯了右上叶部分和心包，并扩散至右侧膈肌。通过部分心包切除术和右上叶楔形切除术切除了一个大肿瘤。切除术后进行了顺铂低渗化疗。该肿瘤具有内胚窦结构、席勒-杜瓦尔体和嗜酸性透明小球，这些是卵黄囊瘤的组织学特征，且血清甲胎蛋白（AFP）值较高。在确诊后，术后全身化疗采用顺铂和依托泊苷。患者8个月后顺利出院。
