Fujita A, Ohbuchi Y, Morikawa T, Takabatake H, Tagaki S, Sekine K
Dept. of Respiratory Disease, Minami-ichijo Hospital.
Gan To Kagaku Ryoho. 1996 Dec;23(14):1981-4.
We experienced three cases of primary mediastinal yolk sac tumor which were resected after 6 courses of BEP chemotherapy with G-CSF support. All cases had high levels of AFP. CT scan revealed an anterior mediastinal tumor infiltrating the surrounding tissue in all cases, and multiple pulmonary nodules in one case. The serum AFP level decreased markedly, but did not return to normal after the chemotherapy was completed. The markedly decreased mediastinal tumor masses were removed with en-bloc resection of the lung and pericardium. Viable tumor cells were not present in the resected tumors. These three cases remain free of disease at present, 3 years, 9 months and 5 months after operation.
我们遇到了3例原发性纵隔卵黄囊瘤，在接受6个疗程的BEP化疗并给予粒细胞集落刺激因子（G-CSF）支持后进行了手术切除。所有病例的甲胎蛋白（AFP）水平都很高。CT扫描显示，所有病例均有前纵隔肿瘤浸润周围组织，其中1例有多个肺结节。化疗完成后，血清AFP水平明显下降，但未恢复正常。通过肺和心包整块切除，切除了明显缩小的纵隔肿瘤肿块。切除的肿瘤中未发现存活的肿瘤细胞。目前，这3例患者在术后3年、9个月和5个月均无疾病复发。
