Hanyu H, Iwamoto T, Takasaki M, Shindo H, Kakizaki D, Abe K
Department of Geriatric Medicine, Tokyo Medical College.
Nihon Ronen Igakkai Zasshi. 1996 Oct;33(10):761-7. doi: 10.3143/geriatrics.33.761.
We studied changes in water diffusion in cerebral white matter in 10 patients with Binswanger's disease (BD), 8 patients with Alzheimer's disease (AD) who had periventricular hyperintensity lesions on T2-weighted images, and 8 age-matched controls. The apparent diffusion coefficients measured in the anterior and posterior white matter were significantly higher in the patients than in the controls, but there was no significant difference between patients with BD and those with AD. The anisotropy ratios, difined as diffusion perpendicular to the nerve fiber direction, were higher in the patients than in the controls. The anisotropy ratio in the anterior white matter was significantly higher in patients with BD than in those with AD, while in the posterior white matter the ratio was significantly higher in patients with AD than in those with BD. These results suggest that in BD and AD cerebral white matter lesions such as periventricular hyperintensity lesions reflect a loss of myelin and axons, and that loss of myelin occurs preferentially in the anterior white matter in BD and in the posterior white matter in AD.
我们研究了10例宾斯旺格病（BD）患者、8例在T2加权图像上有脑室周围高信号病变的阿尔茨海默病（AD）患者以及8例年龄匹配的对照者脑白质中水扩散的变化。患者前、后白质中测得的表观扩散系数显著高于对照者，但BD患者与AD患者之间无显著差异。定义为垂直于神经纤维方向扩散的各向异性比率，患者高于对照者。BD患者前白质的各向异性比率显著高于AD患者，而后白质中AD患者的比率显著高于BD患者。这些结果表明，在BD和AD中，脑室周围高信号病变等脑白质病变反映了髓鞘和轴突的丢失，并且在BD中髓鞘丢失优先发生在前白质，在AD中则优先发生在后白质。
