Konishi T
Department of Neurology, Utano National Hospital.
Rinsho Shinkeigaku. 1996 Aug;36(8):980-5.
A 49-year-old man, who developed generalized symptoms of myasthenia gravis at the age of 30 and had thymomectomy, was recently admitted to our hospital for myasthenic crisis after alpha-interferon (IFN) therapy for his chronic hepatitis C. He had shown only mild ocular symptoms before the start of the IFN intramuscular injection therapy. Three months after the IFN therapy (900MU three times a week after 2 weeks of daily injection), he developed generalized weakness, dysarthria, and dysphagia. After the cessation of his IFN therapy, his conditions became worse in parallel with the increase in the titer of anti-acetylcholine receptor antibody. He required artificial ventilation for 2 weeks during myasthenic crisis and he received food and medication through nasogastric tube. He recovered from myasthenic crisis and could eat orally 4 months after the cessation of interferon therapy, but he still suffered from mild bulbar symptoms 8 months after the IFN cessation. IFN therapy should be avoided for the patients with myasthenia gravis, since it may cause myasthenic crisis, and may aggravate myasthenic symptoms for a long period.
一名49岁男性，30岁时出现重症肌无力的全身症状并接受了胸腺切除术，近期因慢性丙型肝炎接受α干扰素（IFN）治疗后发生重症肌无力危象而入住我院。在开始IFN肌肉注射治疗前，他仅表现出轻度眼部症状。IFN治疗3个月后（每日注射2周后每周3次，每次900MU），他出现了全身无力、构音障碍和吞咽困难。停止IFN治疗后，他的病情随着抗乙酰胆碱受体抗体滴度的升高而恶化。在重症肌无力危象期间，他需要人工通气2周，并通过鼻胃管进食和用药。停止干扰素治疗4个月后，他从重症肌无力危象中康复并能够经口进食，但在停止IFN治疗8个月后仍有轻度延髓症状。重症肌无力患者应避免使用IFN治疗，因为它可能导致重症肌无力危象，并可能长期加重重症肌无力症状。
