Varlet C, Pourriat J L
Département d'Anesthésie-Réanimation, CHU Jean Verdier, Bondy.
Presse Med. 1996 Oct 19;25(31):1453-8.
Necrotizing acute pancreatitis is defined as necrosis of the adipose tissue, interstitial tissue and glandular tissue associated with areas of hemorrhage. Several causes are known predominantly biliary lithiasis and alcoholism. Severe consequences due to the release of pancreatic enzymes include activation of inflammation mediators which can lead to multiple organ failure. Although no therapy has been proven to be effective, progress in intensive care has helped reduce mortality. Rapid diagnosis and evaluation of the severity of illness with specific or general scores (Apache II score) are the keys to rapid management using therapies adapted to the degree of organ failure. Indication for surgery must be established in coordination with surgeons and depends both on the clinical course and computed tomography score.
坏死性急性胰腺炎被定义为与出血区域相关的脂肪组织、间质组织和腺组织坏死。已知有多种病因，主要是胆石症和酒精中毒。胰腺酶释放导致的严重后果包括炎症介质的激活，这可能导致多器官功能衰竭。尽管尚未证明有任何治疗方法有效，但重症监护的进展有助于降低死亡率。使用特定或一般评分（急性生理学及慢性健康状况评分系统II）对疾病严重程度进行快速诊断和评估，是采用适应器官衰竭程度的治疗方法进行快速管理的关键。手术指征必须与外科医生协同确定，并且取决于临床病程和计算机断层扫描评分。
