Hawken M P, Ojoo J C, Morris J S, Kariuki E W, Githui W A, Juma E S, Gathua S N, Kimari J N, Thiong'o L N, Raynes J G, Broadbent P, Gilks C F, Otieno L S, McAdam K P
Clinical Research Centre, Kenya Medical Research Institute, Nairobi, Kenya.
Tuber Lung Dis. 1996 Oct;77(5):444-8. doi: 10.1016/s0962-8479(96)90118-5.
Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya.
To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis.
One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test.
Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group.
While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.
肯尼亚内罗毕肯雅塔国家医院急性内科病房。
确定感染人类免疫缺陷病毒（HIV）-1和未感染HIV-1的结核病患者肾上腺皮质功能不全的患病率。
采用30分钟促肾上腺皮质激素刺激试验，对174例确诊结核病患者（90例HIV-1阳性和84例HIV-1阴性）进行肾上腺皮质功能不全评估。
肺结核患者中有51%、肺外结核患者中有56%的皮质醇反应低于正常水平。然而，两组中感染HIV-1的患者与未感染HIV-1的患者之间在统计学上无显著差异。
虽然皮质醇反应受损在结核病中很常见，但在感染HIV-1的患者中并不比未感染HIV-1的结核病患者更普遍。
