人类免疫缺陷病毒相关结核病患者中肾上腺皮质功能不全的患病率未增加。
No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis.
作者信息
Hawken M P, Ojoo J C, Morris J S, Kariuki E W, Githui W A, Juma E S, Gathua S N, Kimari J N, Thiong'o L N, Raynes J G, Broadbent P, Gilks C F, Otieno L S, McAdam K P
机构信息
Clinical Research Centre, Kenya Medical Research Institute, Nairobi, Kenya.
出版信息
Tuber Lung Dis. 1996 Oct;77(5):444-8. doi: 10.1016/s0962-8479(96)90118-5.
SETTING
Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya.
OBJECTIVE
To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis.
DESIGN
One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test.
RESULTS
Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group.
CONCLUSION
While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.
背景
肯尼亚内罗毕肯雅塔国家医院急性内科病房。
目的
确定感染人类免疫缺陷病毒（HIV）-1和未感染HIV-1的结核病患者肾上腺皮质功能不全的患病率。
设计
采用30分钟促肾上腺皮质激素刺激试验，对174例确诊结核病患者（90例HIV-1阳性和84例HIV-1阴性）进行肾上腺皮质功能不全评估。
结果
肺结核患者中有51%、肺外结核患者中有56%的皮质醇反应低于正常水平。然而，两组中感染HIV-1的患者与未感染HIV-1的患者之间在统计学上无显著差异。
结论
虽然皮质醇反应受损在结核病中很常见，但在感染HIV-1的患者中并不比未感染HIV-1的结核病患者更普遍。
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