Knable M B, Hyde T M, Murray A M, Herman M M, Kleinman J E
National Institute of Mental Health, Intramural Research Program, Washington, DC 20032, USA.
Biol Psychiatry. 1996 Dec 15;40(12):1191-9. doi: 10.1016/S0006-3223(96)00116-3.
We tested the hypothesis that aberrant dopaminergic innervation in frontal and cingulate cortices of schizophrenic patients might be revealed by examining dopamine D1 receptor density in these brain regions. A quantitative autoradiographic assay with [3H]-SCH 23390 was performed with samples from schizophrenic patients, normal controls, neuroleptic-treated controls, and suicides. There was a significant elevation in specific binding of [3H]-SCH 23390 in the intermediate layer of the prefrontal cortex from neuroleptic-treated controls (p = .05). Elevated [3H]-SCH 23390 binding in several layers from prefrontal and cingulate cortex was observed in schizophrenic subjects, although these results did not reach statistical significance. When data from subjects who had received neuroleptics (schizophrenics and neuroleptic controls) were compared to subjects who had not received neuroleptics (normal controls and suicides), there was a significant elevation in receptor density in both the prefrontal (p = .05) and cingulate cortices (p = .03). These data suggest that elevated [3H]-SCH 23390 binding in human prefrontal and cingulate cortices may occur with chronic neuroleptic treatment, although increased receptor density that may exist as a feature of psychotic illnesses cannot be excluded.
我们检验了这样一个假设，即通过检测精神分裂症患者额叶和扣带回皮质中的多巴胺D1受体密度，可能会揭示其异常的多巴胺能神经支配。我们使用[3H]-SCH 23390对精神分裂症患者、正常对照者、接受抗精神病药物治疗的对照者以及自杀者的样本进行了定量放射自显影分析。接受抗精神病药物治疗的对照者前额叶皮质中间层中[3H]-SCH 23390的特异性结合显著升高（p = 0.05）。在精神分裂症患者中，观察到前额叶和扣带回皮质的几层中[3H]-SCH 23390结合升高，尽管这些结果未达到统计学显著性。当将接受过抗精神病药物治疗的受试者（精神分裂症患者和抗精神病药物治疗对照者）的数据与未接受过抗精神病药物治疗的受试者（正常对照者和自杀者）的数据进行比较时，前额叶皮质（p = 0.05）和扣带回皮质（p = 0.03）的受体密度均显著升高。这些数据表明，慢性抗精神病药物治疗可能会导致人类前额叶和扣带回皮质中[3H]-SCH 23390结合升高，尽管不能排除作为精神疾病特征可能存在的受体密度增加。
