Smith G N, MacEwan G W, Altman S, Meistrich B, Lapointe J S, Kopala L, Honer W G
Refractory Psychosis Program, Riverview Hospital, Port Coquitlam, British Columbia, Canada.
Biol Psychiatry. 1996 Dec 15;40(12):1200-8. doi: 10.1016/S0006-3223(96)00111-4.
Birth problems can lead to changes in brain morphology in the general population and an increased prevalence of both birth problems and altered brain morphology are found in patients with schizophrenia. The purpose of this study was to test the hypothesis that these two findings are related. Birth history and the size of ventricular and sulcal spaces from nine regions of the brain were assessed in 80 male subjects with schizophrenia. No differences were found between patients with and those without a history of birth problems for the size of any brain space; however, ventricular size increased significantly with age in patients who had no birth complications but not in patients with a history of birth problems. The size of cortical sulci increased with age in patients with and those without a history of birth problems. These results suggest that region-specific rates of change in size may identify clinically meaningful patients subgroups.
出生问题可导致普通人群大脑形态发生改变，而精神分裂症患者中出生问题和大脑形态改变的患病率均有所增加。本研究的目的是检验这两个发现相关这一假设。对80名男性精神分裂症患者的出生史以及大脑九个区域的脑室和脑沟空间大小进行了评估。在任何脑区空间大小方面，有出生问题病史的患者与无出生问题病史的患者之间未发现差异；然而，无出生并发症的患者脑室大小随年龄显著增加，而有出生问题病史的患者则不然。有和无出生问题病史的患者脑沟大小均随年龄增加。这些结果表明，特定区域大小变化率可能识别出具有临床意义的患者亚组。
