Okui T, Endoh D, Arai S, Isogai E, Hayashi M
Hokkaido Institute of Public Health, Sapporo, Japan.
J Vet Med Sci. 1996 Nov;58(11):1067-71. doi: 10.1292/jvms.58.11_1067.
The cross-sensitivity of X-ray-hypersensitive lung fibroblasts from LEC strain (LEC) rats to other DNA-damaging agents was examined. The LEC cells were 2- to 3-fold more sensitive to bleomycin (BLM) that induces DNA double-strand breaks, and to a cross-linking agent, mitomycin C, than the cells from WKAH strain (WKAH) rats, while they were slightly sensitive to alkylating agents, ethyl nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine, but not to UV-irradiation. Although no difference was observed in the initial yields of DNA double-strand breaks induced by BLM between LEC and WKAH cells, the repair process of DNA double-strand breaks was significantly slower in LEC cells than in WKAH cells.
研究了来自LEC品系（LEC）大鼠的X射线超敏肺成纤维细胞对其他DNA损伤剂的交叉敏感性。与来自WKAH品系（WKAH）大鼠的细胞相比，LEC细胞对诱导DNA双链断裂的博来霉素（BLM）和交联剂丝裂霉素C的敏感性高2至3倍，而它们对烷基化剂乙基亚硝基脲和N-甲基-N'-硝基-N-亚硝基胍略有敏感，但对紫外线照射不敏感。尽管在LEC细胞和WKAH细胞之间，由BLM诱导的DNA双链断裂的初始产量没有差异，但LEC细胞中DNA双链断裂的修复过程明显比WKAH细胞慢。
