Van Meerbeeck J, Weyler J, Thibaut A, Vansteenkiste J, Aumann J, Deneffe G, Galdermans D, Haelterman M, Joos G, Noppen M, Pinson P, Tasson J, van den Eeckhout A, Uydebrouck M
Task Group on Lung Cancer-VRGT, Brussels, Belgium.
Lung Cancer. 1996 Nov;15(3):281-95. doi: 10.1016/0169-5002(95)00593-5.
Patient and tumour characteristics of 23 patients presenting with a second primary lung cancer were analysed and compared with 534 patients with radically resected stage 1 non-small cell lung cancer (NSCLC). None of these characteristics is associated with a higher occurrence rate for second primary lung cancer. Prognosis in the latter patients is significantly worse than after resection of a 'solitary' NSCLC: the median survival time (MST) after resection of the first tumour is 50 months; after diagnosis of the second tumour only 14 months. Surgically retreated patients have a prognosis that is similar to that after resection of a 'solitary' NSCLC. No separate independent prognostic factors responsible for this survival difference could be isolated. Squamous histology and central location are associated with a longer recurrence free survival time. We conclude that the occurrence of a second primary lung cancer can not be predicted based on patient or tumour characteristics and that only surgical retreatment offers a chance of long survival in these patients.
对23例出现第二原发性肺癌的患者的患者和肿瘤特征进行了分析，并与534例接受根治性切除的I期非小细胞肺癌（NSCLC）患者进行了比较。这些特征均与第二原发性肺癌的较高发生率无关。后一组患者的预后明显比切除“孤立性”NSCLC后的预后差：切除第一个肿瘤后的中位生存时间（MST）为50个月；诊断出第二个肿瘤后仅14个月。接受手术治疗的患者的预后与切除“孤立性”NSCLC后的预后相似。无法分离出导致这种生存差异的单独独立预后因素。鳞状组织学和中央位置与更长的无复发生存时间相关。我们得出结论，无法根据患者或肿瘤特征预测第二原发性肺癌的发生，并且只有手术治疗才能为这些患者提供长期生存的机会。
