Kim B S, Song K Y, Youn J I, Chung J H
Department of Dermatology, Seoul National University, College of Medicine, Chongno-Gu, Korea.
Clin Exp Dermatol. 1996 Jul;21(4):315-7. doi: 10.1111/j.1365-2230.1996.tb00107.x.
Involvement of the nail unit in pemphigus vulgaris is thought to be uncommon. However, trachyonychia, nail atrophy, onychomadesis, onycholysis, nail bed erosion, onychoschizia, subungual haemorrhage, nail pitting, nail plate discoloration, cross-ridging of nail plate, Beau's line and paronychia have been reported. These manifestations may be due either to secondary extension of the bulla adjacent to the nail or primary involvement of the nail bed, nail matrix and nail fold. We report four patients with pemphigus vulgaris who developed paronychia with a corresponding exacerbation of their cutaneous lesions. Nail fold biopsy and direct immunofluorescence revealed features of permphigus vulgaris. Treatment with immunosuppressive agents showed simultaneous improvement of both cutaneous and nail lesions.
寻常型天疱疮累及甲单位被认为不常见。然而，已有报道出现糙甲症、甲萎缩、甲脱失、甲剥离、甲床糜烂、甲裂、甲下出血、甲凹点、甲板变色、甲板横行嵴、博氏线和甲沟炎。这些表现可能是由于邻近指甲的水疱继发性扩展，或甲床、甲母质和甲襞原发性受累所致。我们报告了4例寻常型天疱疮患者，他们出现了甲沟炎，同时皮肤损害也相应加重。甲襞活检和直接免疫荧光检查显示为寻常型天疱疮的特征。免疫抑制剂治疗使皮肤和指甲损害同时得到改善。
