El-Komy M M, Abdel Halim D M, Samir N, Hegazy R A, Gawdat H I, Shoeb S A
Dermatology Department, Faculty of Medicine, Cairo University.
Microbiology and Immunology Department, Faculty of Medicine, Cairo University.
Int J Womens Dermatol. 2015 Mar 19;1(2):82-84. doi: 10.1016/j.ijwd.2015.01.005. eCollection 2015 Jun.
Pemphigus vulgaris (PV) patients receiving immunosuppressive therapy may develop nail alterations resulting from infection, skin disorder, or drug regimen.
This study aims to describe nail changes in PV female patients receiving immunosuppressive therapy and to report the frequency of associated fungal and bacterial growth in the patients' nails.
Twenty-five female PV patients who had at least one acquired finger or toenail abnormality and had been administered at least one immunosuppressive drug were included in the study. Nail alterations were recorded. Nail scrapings were collected from abnormal nails for fungal and bacterial examination.
Positive fungal and bacterial cultures were detected in 20 (80%) of patients' nail samples. Five patients reported nail alterations coinciding with disease onset, whereas 13 reported nail changes after administration of immunosuppressive therapy.
Lack of a control group (patients on similar immunosuppressive medications for conditions other than PV) which would have further supported the findings demonstrated in this observational study.
Nail abnormalities in severe PV patients are frequently associated with fungal and bacterial growth. Immunosuppressive therapy potentially initiates such changes.
接受免疫抑制治疗的寻常型天疱疮（PV）患者可能会因感染、皮肤疾病或药物治疗方案而出现指甲改变。
本研究旨在描述接受免疫抑制治疗的PV女性患者的指甲变化，并报告患者指甲中相关真菌和细菌生长的频率。
本研究纳入了25名患有至少一种后天性手指或脚趾甲异常且至少服用过一种免疫抑制药物的PV女性患者。记录指甲改变情况。从异常指甲上采集指甲屑进行真菌和细菌检查。
在20名（80%）患者的指甲样本中检测到真菌和细菌培养阳性。5名患者报告指甲改变与疾病发作同时出现，而13名患者报告在接受免疫抑制治疗后出现指甲变化。
缺乏对照组（因除PV以外的疾病而服用类似免疫抑制药物的患者），这将进一步支持本观察性研究中所展示的结果。
重度PV患者的指甲异常常与真菌和细菌生长相关。免疫抑制治疗可能引发此类变化。
