Thatte L, Vaamonde C A
University of Miami School of Medicine, Florida, USA.
Postgrad Med. 1996 Dec;100(6):83-4, 87-8, 91 passim. doi: 10.3810/pgm.1996.12.128.
Although the exact incidence of drug-induced nephrotoxicity is not known, it is important for clinicians to be aware of the risks in certain patients and to know which drugs are the most commonly implicated. The latter include radiocontrast agents, aminoglycosides, nonsteroidal anti-inflammatory drugs, and angiotensin-converting enzyme inhibitors. Other medications also have nephrotoxic potential when they are prescribed in specific patient populations. Renal injury may be transient and mild in many cases, but recognition of the patient at high risk and application of preventive measures are essential to avoid a severe and protracted course.
尽管药物性肾毒性的确切发生率尚不清楚，但临床医生了解某些患者面临的风险以及哪些药物是最常见的相关药物非常重要。后者包括放射造影剂、氨基糖苷类、非甾体抗炎药和血管紧张素转换酶抑制剂。其他药物在特定患者群体中使用时也有肾毒性的潜在风险。在许多情况下，肾损伤可能是短暂且轻微的，但识别高危患者并采取预防措施对于避免严重和持久的病程至关重要。
