双环[2.2.2]辛烷衍生物的合成与药理特性：7-异丙基-6-甲基-和1-异丙基-4-甲基双环[2.2.2]辛-5-烯-2,3-二羧酰亚胺的N-(1-芳基-4-哌嗪基-丁基)衍生物
Synthesis and pharmacological profile of bicyclo[2.2.2]octane derivatives: N-(1-aryl-4-piperazinyl-butyl) derivatives of 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo[2.2.2]oct-5-ene-2,3-dicarboxyimide.
作者信息
Zawadowski T, Skowron A A, Suski S, Rump S, Jakowicz I
机构信息
Department of Medical Chemistry, School of Medicine, Warsaw, Poland.
出版信息
Acta Pol Pharm. 1995 Mar-Apr;52(2):129-32.
PMID:8960243
Abstract
The new class of compounds characterized by anxiolytic or antidepressive properties, including a number of N-(1-aryl-4-piperazinylbutyl) derivatives of the two isomers: 7-isopropyl-6-methyl- and 1-isopropyl-4-methylbicyclo [2.2.2]oct-5-ene-2,3-dicarboxyimide was synthesized. Two compounds were selected for further pharmacological study.
摘要
合成了一类具有抗焦虑或抗抑郁特性的新型化合物，包括两种异构体的多种N-(1-芳基-4-哌嗪基丁基)衍生物：7-异丙基-6-甲基-和1-异丙基-4-甲基双环[2.2.2]辛-5-烯-2,3-二羧酸亚胺。选择了两种化合物进行进一步的药理学研究。
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