Zembrzuska-Sadkowska E, Parnowska W, Werakso B, Najer A
Drug Institute, Warsaw, Poland.
Acta Pol Pharm. 1995 Mar-Apr;52(2):161-71.
The majority of tested Gram-negative strains isolated from the hospital environment were resistant to 6-14 used antibiotics. The greatest resistance was shown by three strains: Enterobacter cloacae, Proteus mirabilis and Ps. maltophilia, which were resistant to all tested drugs. The most effective antibiotic was gentamicin, at least against half of bacteria belonging to Enterobacteriaceae family, to 90% of strains from Pseudomonas genus and to all other Gram-negative rods. Cephtazidim, cephotaxim, colistin and carbenicillin were effective only to 60-70% of Enterobacteriaceae family strains, whereas ampicillin and tetracycline to 70% of Pseudomonas genus. Other Gram-negative bacilli were more susceptible to antibiotics. Cephalothin was ineffective to all tested strains.
从医院环境中分离出的大多数革兰氏阴性菌株对6 - 14种使用过的抗生素具有抗性。三种菌株表现出最高的抗性:阴沟肠杆菌、奇异变形杆菌和嗜麦芽窄食单胞菌,它们对所有测试药物均有抗性。最有效的抗生素是庆大霉素,至少对一半的肠杆菌科细菌、90%的假单胞菌属菌株以及所有其他革兰氏阴性杆菌有效。头孢他啶、头孢噻肟、黏菌素和羧苄青霉素仅对60 - 70%的肠杆菌科菌株有效,而氨苄青霉素和四环素对70%的假单胞菌属菌株有效。其他革兰氏阴性杆菌对抗生素更敏感。头孢噻吩对所有测试菌株均无效。