Zembrzuska-Sadkowska E, Parnowska W, Werakso B, Najer A
Drug Institute, Warsaw, Poland.
Acta Pol Pharm. 1995 Jan-Feb;52(1):77-85.
No strains resistant to all tested antibiotics were found among the 33 Gram-positive and 17 Gram-negative bacteria isolated from non-parenteral drugs and purified water. Three strains: S. aureus, coagulase-negative staphylococcus and B. cereus have been found to be resistant to 6-8 antibiotics, whereas six Gram-negative strains belonging to Enterobacter agglomerans and Ps. aeruginsosa were resistant to 6-12 antibiotics. The most effective agent against all tested Gram-positive bacteria was cephaloridine, and erythromycin against the staphylococci. Tetracycline and ceftazidim were the least effective. Gentamycin was the only antibiotic effective to all Gram-negative strains, and ceftazidim to most of them. Cefsulodin was ineffective to Ps. aeruginosa.
从非注射用药物和纯化水中分离出的33株革兰氏阳性菌和17株革兰氏阴性菌中,未发现对所有测试抗生素均耐药的菌株。发现3株菌株:金黄色葡萄球菌、凝固酶阴性葡萄球菌和蜡样芽孢杆菌对6 - 8种抗生素耐药,而6株属于聚团肠杆菌和铜绿假单胞菌的革兰氏阴性菌株对6 - 12种抗生素耐药。对所有测试革兰氏阳性菌最有效的药物是头孢菌素,对葡萄球菌最有效的是红霉素。四环素和头孢他啶效果最差。庆大霉素是对所有革兰氏阴性菌株都有效的唯一抗生素,头孢他啶对大多数革兰氏阴性菌株有效。头孢磺啶对铜绿假单胞菌无效。