1,2,3,4-四氢异喹啉衍生物的合成及药理性质
Synthesis and pharmacological properties of 1,2,3,4-tetrahydroisoquinoline derivatives.
作者信息
Brzezińska E
机构信息
Institute of Chemistry and Technology of Drugs, School of Medicine, Lódź, Poland.
出版信息
Acta Pol Pharm. 1996 Jan-Feb;53(1):25-9.
PMID:8960281
Abstract
Selected 2-isopropyl-4,6,8-trihydroxy-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized and evaluated as beta-adrenoreceptor agents. These orciprenaline derivatives were found as week, partial agonists of beta-adrenoreceptors. Some of them showed good binding properties.
摘要
合成了选定的2-异丙基-4,6,8-三羟基-1,2,3,4-四氢异喹啉衍生物，并将其作为β-肾上腺素能受体药物进行评估。发现这些奥西那林衍生物是β-肾上腺素能受体的弱部分激动剂。其中一些表现出良好的结合特性。
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