一些新型4,5-二氢-1H-1,2,4-三唑-5-酮的合成及其生物活性
Synthesis and biological activities of some new 4,5-dihydro-1H-1,2,4-triazol-5-ones.
作者信息
Demirbas A, Johansson C B, Duman N, Ikizler A A
机构信息
Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
出版信息
Acta Pol Pharm. 1996 Mar-Apr;53(2):117-21.
PMID:8960286
Abstract
The reactions of 3-alkyl(aryl)-4-phenylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones with appropriate alkyl halides via sodio derivatives were studied and the corresponding 1-alkyl-3-alkyl(aryl)-4-phenylamino-4,5-dihydro-1H-1,2,4-traizol-5 -ones were synthesized. Next, the new compounds were tested for their in vitro antimicrobial activities.
摘要
研究了3-烷基（芳基）-4-苯基氨基-4,5-二氢-1H-1,2,4-三唑-5-酮通过钠衍生物与适当的卤代烷的反应，并合成了相应的1-烷基-3-烷基（芳基）-4-苯基氨基-4,5-二氢-1H-1,2,4-三唑-5-酮。接下来，对新化合物进行了体外抗菌活性测试。
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