Tang D, Lee K Y, Qi Z, Matsuura I, Wang J H
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
Biochem Cell Biol. 1996;74(4):419-29. doi: 10.1139/o96-046.
Neuronal Cdc2-like kinase, Nclk, is a heterodimer of cyclin-dependent protein kinase 5 (Cdk5) and a 25-kDa essential regulatory subunit that is derived from a 35-kDa brain- and neuron-specific protein. This protein is called neuronal Cdk5 activator, p25/35nck5a. Nclk is one of the best characterized Cdc2 family kinases whose primary function is not cell cycle related. It has been suggested that this protein kinase plays important roles in neurocytoskeleton dynamics and its loss of regulation has been implicated in Alzheimer pathology. As a member of the Cdc2-like kinase family, Nclk shares many common properties with other members of the Cdc2-like kinase family. It also possesses unique characteristics that may be related to its distinct and noncell cycle related functions. The regulatory and functional properties of Nclk are reviewed in this communication.
神经元Cdc2样激酶（Nclk）是细胞周期蛋白依赖性蛋白激酶5（Cdk5）与一个25 kDa的必需调节亚基组成的异二聚体，该调节亚基源自一种35 kDa的脑和神经元特异性蛋白。这种蛋白被称为神经元Cdk5激活剂，即p25/35nck5a。Nclk是特征最明确的Cdc2家族激酶之一，其主要功能与细胞周期无关。有人提出，这种蛋白激酶在神经细胞骨架动力学中起重要作用，其调节失控与阿尔茨海默病病理学有关。作为Cdc2样激酶家族的一员，Nclk与Cdc2样激酶家族的其他成员具有许多共同特性。它还具有一些独特的特征，这些特征可能与其独特的、与细胞周期无关的功能有关。本文对Nclk的调节和功能特性进行了综述。
