Lee K Y, QI Z, Yu Y P, Wang J H
Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Canada.
Int J Biochem Cell Biol. 1997 Jul;29(7):951-8. doi: 10.1016/s1357-2725(97)00048-4.
Neuronal Cdc2-like kinase, Nclk, is a heterodimer of a Cdk5 catalytic subunit and a 25 kDa regulatory subunit derived proteolytically from a neuron- and central nervous system-specific 35 kDa protein. The regulatory subunit is mandatory for kinase activity, hence it is designated the neuronal Cdk5 activator, p25/p35nck5a. Nclk has been suggested to play a regulatory role in neuro-cytoskeleton dynamics and in neuronal differentiation. In addition to the activation by Nck5a, Cdk5 is regulated by other mechanisms including additional activator proteins and inhibition by phosphorylation of specific amino acid residues. While Nclk shares common catalytic and regulatory properties with other members of the cdc2-like kinase family, it also displays unique characteristics that may be important for its neuronal functions.
神经元Cdc2样激酶（Nclk）是Cdk5催化亚基与一个25 kDa调节亚基的异二聚体，该调节亚基由一种神经元和中枢神经系统特异性的35 kDa蛋白经蛋白水解产生。调节亚基对于激酶活性是必需的，因此它被命名为神经元Cdk5激活剂，即p25/p35nck5a。有人提出Nclk在神经细胞骨架动力学和神经元分化中发挥调节作用。除了被Nck5a激活外，Cdk5还受其他机制调节，包括其他激活蛋白以及特定氨基酸残基磷酸化所导致的抑制作用。虽然Nclk与cdc2样激酶家族的其他成员具有共同的催化和调节特性，但它也表现出可能对其神经元功能很重要的独特特征。
