Koh W J, Mayberg M R, Chambers J, Lindsley K L, Tran A, Rasey J S, Griffin T W
Department of Radiation Oncology, University of Washington, Seattle 98195, USA.
Int J Radiat Oncol Biol Phys. 1996 Nov 1;36(4):829-34. doi: 10.1016/s0360-3016(96)00408-7.
The potential role of radiation in the prevention of coronary artery restenosis after angioplasty has generated much recent interest. Animal research and pilot clinical efforts have focused primarily on intraluminal methods of radiation delivery. This article reviews the experience to date with external beam radiation in restenosis prevention and suggests issues that should be considered from the standpoint of both external beam and intravascular radiotherapy. External beam radiation can certainly play an effective role in clinical studies of coronary artery restenosis, and a multicenter randomized trial of external beam radiation after coronary angioplasty has been initiated.
放射在血管成形术后预防冠状动脉再狭窄中的潜在作用最近引起了广泛关注。动物研究和初步临床研究主要集中在腔内放射递送方法上。本文回顾了迄今为止外照射在预防再狭窄方面的经验，并从外照射和血管内放射治疗的角度提出了应考虑的问题。外照射在冠状动脉再狭窄的临床研究中肯定能发挥有效作用，一项冠状动脉血管成形术后外照射的多中心随机试验已经启动。
