Pujol J, Kulisevsky J, Moreno A, Deus J, Alonso J, Balanzó J, Martí-Vilalta J L, Capdevila A
Magnetic Resonance Center of Pedralbes, Barcelona, Spain.
Neurology. 1996 Dec;47(6):1526-30. doi: 10.1212/wnl.47.6.1526.
In patients with chronic hepatic encephalopathy, proton magnetic resonance spectroscopy can be used to detect specific metabolic abnormalities in the brain; MRI shows a hyperintense globus pallidus on T1-weighted sequences. We investigated the relationship between these two MR findings in a series of 25 patients with the use of quantitative data and a multiple regression analysis model. The cerebral increase in glutamine compounds and the decrease in myoinositol and choline correlated separately with globus pallidus hyperintensity, and each was complementary in accounting for this imaging finding. Such as association suggests that spectroscopic and imaging alterations are two different expressions of the reversible events that occur in the brain of patients with hepatic encephalopathy in that both disappear after liver transplantation. Globus pallidus hyperintensity seems to be a global indicator of the cerebral metabolic disorder, and the spectroscopic pattern denotes the specific metabolic alterations.
在慢性肝性脑病患者中，质子磁共振波谱可用于检测脑部特定的代谢异常；磁共振成像（MRI）在T1加权序列上显示苍白球高信号。我们使用定量数据和多元回归分析模型，对25例患者的这两种磁共振成像结果之间的关系进行了研究。脑内谷氨酰胺化合物增加以及肌醇和胆碱减少分别与苍白球高信号相关，且二者在解释这一影像学表现时具有互补性。这种关联表明，波谱和成像改变是肝性脑病患者脑内发生的可逆性事件的两种不同表现形式，因为二者在肝移植后均消失。苍白球高信号似乎是脑代谢紊乱的一个整体指标，而波谱模式则表示特定的代谢改变。
