Varvarigou Anastasia A, Petsali Maria, Vassilakos Pavlos, Beratis Nicholas G
Department of Pediatrics, University of Patras, Patras, Greece.
J Perinat Med. 2006;34(6):466-70. doi: 10.1515/JPM.2006.091.
To investigate the effect of tobacco smoke on cord blood cortisol concentrations.
Cortisol concentrations were measured in cord blood from 211 term newborns of smoking and 211 term newborns of nonsmoking mothers; 48 and 36 newborns were delivered by cesarean section, respectively. In 16 cases, in addition to cord blood, maternal venous blood was obtained at delivery.
The median cord blood cortisol concentration in neonates of the smoking and the nonsmoking mothers was 23 and 13 microg/dL, respectively (P<0.0001). Cortisol concentrations were greater in the newborns whose mothers smoked, when compared to corresponding controls, whether they were delivered vaginally or by cesarean section. In the newborns delivered by cesarean section, there was a positive correlation between number of cigarettes smoked/day and cortisol concentrations, as well as a negative correlation between cortisol concentrations and neonatal length. There was no significant correlation between cortisol concentrations and birth weight or head circumference. Cortisol concentrations in the cord blood of neonates whose mothers were smokers and nonsmokers were by 29% and 45% lower from those measured in their mothers, respectively.
Although a causal relationship between maternal smoking and high cortisol concentrations in cord blood was not established, the findings are in accordance with previous reports indicating elevated stress-hormones in newborns whose mothers smoked during pregnancy.
研究烟草烟雾对脐血皮质醇浓度的影响。
测量了211名母亲吸烟的足月儿和211名母亲不吸烟的足月儿的脐血皮质醇浓度；分别有48名和36名新生儿通过剖宫产分娩。16例中，除脐血外，分娩时还采集了母亲的静脉血。
母亲吸烟组和不吸烟组新生儿脐血皮质醇浓度中位数分别为23和13μg/dL（P<0.0001）。与相应对照组相比，母亲吸烟的新生儿无论经阴道分娩还是剖宫产，其皮质醇浓度均较高。在剖宫产分娩的新生儿中，每日吸烟量与皮质醇浓度呈正相关，皮质醇浓度与新生儿身长呈负相关。皮质醇浓度与出生体重或头围之间无显著相关性。母亲吸烟和不吸烟的新生儿脐血皮质醇浓度分别比其母亲测得的浓度低29%和45%。
虽然未确定母亲吸烟与脐血高皮质醇浓度之间的因果关系，但研究结果与之前的报告一致，即母亲在孕期吸烟的新生儿应激激素升高。
