Manfro G G, Otto M W, McArdle E T, Worthington J J, Rosenbaum J F, Pollack M H
Anxiety Disorders Program, Massachusetts General Hospital, Boston, MA 02114, USA.
J Affect Disord. 1996 Nov 25;41(2):135-9. doi: 10.1016/s0165-0327(96)00081-x.
The authors examined the incidence of significant life events during the year prior to the onset of panic disorder and its relationship to childhood and family history of anxiety difficulties, comorbidity, and the course of illness in 223 panic patients followed in a naturalistic study of panic disorder. Similar to previous reports, antecedent negative life events occurred in the majority (80%) of patients. Patients with a childhood history of anxiety and comorbid adulthood major depression were more likely to report an antecedent, stressful life event. Antecedent events were not linked with comorbid, adulthood anxiety disorders or a family history of anxiety difficulties. Despite its associations with childhood anxiety pathology and adulthood major depression, the presence of an identifiable antecedent at the onset of panic disorder was not associated with the subsequent severity or course of the disorder.
作者在一项针对惊恐障碍的自然主义研究中，对223名惊恐障碍患者进行了检查，以探究惊恐障碍发作前一年中重大生活事件的发生率，及其与童年和家族焦虑症病史、共病情况以及疾病进程之间的关系。与之前的报告相似，大多数（80%）患者发生过先前的负面生活事件。有童年焦虑症病史且成年后患有重度抑郁症的患者更有可能报告先前发生的应激性生活事件。先前事件与成年期共病焦虑症或焦虑症家族史无关。尽管惊恐障碍发作时存在可识别的先前事件与童年焦虑病理和成年期重度抑郁症有关，但它与该障碍随后的严重程度或进程无关。
