Hashimoto S, Wolfe E, Guglielmo B, Shanks R, Sundelof J, Pittet J F, Thomas E, Wiener-Kronish J
Department of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine, Japan.
J Antimicrob Chemother. 1996 Nov;38(5):809-18. doi: 10.1093/jac/38.5.809.
Aerosolization of imipenem/cilastatin was compared with continuous intravenous infusions of the antibiotic for pharmacokinetic/pharmacodynamic analysis. The concentrations of imipenim/cilastatin in bronchoalveolar lavage fluids (BAL) obtained from rats exposed to the aerosolized antibiotic were significantly greater than the concentrations in BAL in the rats that had received intravenous infusions of imipenem/cilastatin. The two methods of antibiotic delivery were compared for their effects on bacterial-induced lung injury in rats that had Pseudomonas aeruginosa instilled into their airspaces. The aerosolization of antibiotic was associated with significantly decreased bacterial-induced lung injury. The high concentrations of antibiotic in the airspaces secondary to aerosolization appears to kill bacteria more quickly and preserve lung epithelial and endothelial integrity better than systemic delivery of the same antibiotic.
将亚胺培南/西司他丁雾化与连续静脉输注该抗生素进行比较，以进行药代动力学/药效学分析。从暴露于雾化抗生素的大鼠获得的支气管肺泡灌洗液（BAL）中亚胺培南/西司他丁的浓度显著高于接受亚胺培南/西司他丁静脉输注的大鼠BAL中的浓度。比较了两种抗生素给药方法对将铜绿假单胞菌注入气腔的大鼠细菌诱导的肺损伤的影响。抗生素雾化与细菌诱导的肺损伤显著降低有关。雾化后气腔中高浓度的抗生素似乎比相同抗生素的全身给药能更快地杀死细菌，并更好地保持肺上皮和内皮的完整性。
