Scalzo M, Orlandi C, Simonetti N, Cerreto F
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Roma, Italy.
J Pharm Pharmacol. 1996 Nov;48(11):1201-5. doi: 10.1111/j.2042-7158.1996.tb03921.x.
Cosmetic or pharmaceutical formulations containing hydrophilic polymers of natural or synthetic origin, may be more exposed to successful microbial contamination because of a polymer-preservative interaction. The experimental data reported in this paper relate to the possible interference of Carbopol 940 with methyl parahydroxybenzoate. Results show that this hydrophilic polymer, widely employed in many formulations, exerts, on the contrary, an interesting synergism on microbicidal activity of the preserving agent against E. coli and P. Aeruginosa. A reduction in microbicidal activity against S. aureus and C. albicans is observed for a polymer concentration higher than that needed for anti-Gram-negative synergy.
含有天然或合成来源亲水性聚合物的化妆品或药物制剂，由于聚合物与防腐剂的相互作用，可能更容易受到微生物污染。本文报道的实验数据涉及卡波姆940对甲基对羟基苯甲酸酯可能的干扰。结果表明，这种广泛应用于许多制剂中的亲水性聚合物，相反地，对防腐剂对大肠杆菌和铜绿假单胞菌的杀菌活性发挥了有趣的协同作用。当聚合物浓度高于抗革兰氏阴性菌协同作用所需浓度时，观察到对金黄色葡萄球菌和白色念珠菌的杀菌活性降低。
