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负载尿囊素/β-环糊精的具有黏膜黏附性和抗菌性的卡波姆凝胶作为再生医学支架

Mucoadhesive and Antimicrobial Allantoin/β Cyclodextrins-Loaded Carbopol Gels as Scaffolds for Regenerative Medicine.

作者信息

Filip Daniela, Macocinschi Doina, Zaltariov Mirela-Fernanda, Gafitanu Carmen Anatolia, Tuchilus Cristina Gabriela, Bele Adrian, Ciubotaru Bianca-Iulia, Stoleru Elena, Bargan Alexandra

机构信息

"Petru Poni" Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, 700487 Iasi, Romania.

Department of Pharmaceutical Technology, Faculty of Pharmacy, "Gr. T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.

出版信息

Gels. 2022 Jul 2;8(7):416. doi: 10.3390/gels8070416.

DOI:10.3390/gels8070416
PMID:35877501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9320337/
Abstract

Allantoin and its β-cyclodextrin and hydroxypropyl-β-cyclodextrin inclusion complexes 1:1 have been used to prepare carbopol-based mucoadhesive gels. The gelation process occurred by adjustment with glycerol 10% in the presence of triethanolamine. The structural features induced by the presence of allantoin and the corresponding β-cyclodextrins inclusion complexes have been first investigated by infrared spectroscopy highlighting strong interactions within the gels network and ideal crosslinks for the self-healing behavior. The hydrophilicity of the gels was investigated by the determination of the surface tension parameters and the free energy of hydration. The interfacial free energy values indicated prolonged biocompatibility with blood. The gels-water molecule interactions in terms of sorption, permeability, and diffusion coefficients were evaluated by dynamic vapor sorption analysis. The self-assembly process through intermolecular H-bonding, the high hydrophilicity, the mechanical performance, the hydrolytic stability in simulated biological media, the biocompatibility with normal human dermal fibroblast (NHDF) cells, the mucoadhesivity and antimicrobial activity on selected microorganism species ( and ) of the allantoin-based gels recommend them as promising scaffold alternatives in regenerative medicine.

摘要

尿囊素及其与β-环糊精和羟丙基-β-环糊精1:1的包合物已被用于制备基于卡波姆的黏膜黏附凝胶。在三乙醇胺存在下，通过用10%甘油调节发生凝胶化过程。首先通过红外光谱研究了尿囊素和相应的β-环糊精包合物的存在所诱导的结构特征，突出了凝胶网络内的强相互作用以及自修复行为的理想交联。通过测定表面张力参数和水化自由能来研究凝胶的亲水性。界面自由能值表明与血液的生物相容性延长。通过动态蒸汽吸附分析评估了凝胶与水分子在吸附、渗透性和扩散系数方面的相互作用。基于尿囊素的凝胶通过分子间氢键的自组装过程、高亲水性、机械性能、在模拟生物介质中的水解稳定性、与正常人皮肤成纤维细胞（NHDF）的生物相容性、黏膜黏附性以及对选定微生物物种的抗菌活性，使其成为再生医学中很有前景的支架替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/0ea231af841a/gels-08-00416-g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/61b23b3ab4b2/gels-08-00416-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/b449d069497b/gels-08-00416-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/3002297ff4bd/gels-08-00416-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/cbc9c71705f4/gels-08-00416-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/53bacd4db7e1/gels-08-00416-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/0ea231af841a/gels-08-00416-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/003efeda553f/gels-08-00416-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/5b3a417d4d03/gels-08-00416-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/958053b2fb3c/gels-08-00416-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/f3b8a6bddfee/gels-08-00416-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/d422872b3cb8/gels-08-00416-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/260d5b10697f/gels-08-00416-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/b76916958fbf/gels-08-00416-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/6f76c8ef5d90/gels-08-00416-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/61b23b3ab4b2/gels-08-00416-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/b449d069497b/gels-08-00416-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/3002297ff4bd/gels-08-00416-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/cbc9c71705f4/gels-08-00416-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/53bacd4db7e1/gels-08-00416-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25ff/9320337/0ea231af841a/gels-08-00416-g014.jpg

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