Hunt M J, Salisbury E L, Painter D M, Lee S
Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Australas J Dermatol. 1996 Nov;37(4):196-8. doi: 10.1111/j.1440-0960.1996.tb01053.x.
A 56-year-old male presented with a pruritic, generalized vesiculobullous eruption. His past history revealed classical symptoms of limited Hailey-Hailey disease for 34 years. Clinically, vesicles, bullae and occasional pustules were present and multiple biopsies confirmed this to be an unusual presentation of Hailey-Hailey disease. Various therapeutic modalities including topical and oral antibiotics, oral prednisone and dapsone failed to achieve sustained remission. Treatment with low-dose oral etretinate (25 mg daily) produced marked clinical improvement with complete suppression of new vesicle formation after 6 weeks.
一名56岁男性出现瘙痒性全身性水疱大疱性皮疹。他的既往史显示有34年局限性黑利-黑利病的典型症状。临床上可见水疱、大疱及偶尔的脓疱，多次活检证实这是黑利-黑利病的一种不寻常表现。包括外用和口服抗生素、口服泼尼松和氨苯砜在内的各种治疗方法均未能实现持续缓解。低剂量口服阿维A（每日25毫克）治疗6周后临床症状明显改善，新水疱形成完全得到抑制。
