Lemieux Alexandre, Funaro Deana
Department of Dermatology, Centre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada.
SAGE Open Med Case Rep. 2020 Feb 16;8:2050313X20905678. doi: 10.1177/2050313X20905678. eCollection 2020.
Hailey-Hailey disease is an autosomal dominant genodermatosis leading to chronic hyperkeratotic and fissured lesions in the intertriginous areas. We present a 53-year-old woman with a case of vulvar and inguinal Hailey-Hailey disease resistant to usual treatments. She was efficiently treated with alitretinoin 10 mg daily combined with injections of onabotulinumtoxinA every 9 months. The combination led to an almost complete resolution of the lesions and symptoms at follow-ups.
黑利-黑利病是一种常染色体显性遗传性皮肤病，可导致皮肤褶皱部位出现慢性角化过度和裂隙性皮损。我们报告一例53岁女性患有的外阴及腹股沟黑利-黑利病，该病例对常规治疗耐药。她接受了每日10毫克阿利维A酸联合每9个月注射一次A型肉毒毒素的治疗，治疗效果显著。随访时皮损和症状几乎完全消退。
