Kim Y I
Department of Medicine, University of Toronto, Ontario, Canada.
Nutr Rev. 1996 Aug;54(8):248-52. doi: 10.1111/j.1753-4887.1996.tb03943.x.
One of the greatest challenges in managing Crohn's disease is to maintain remission. Although pharmacologic approaches to maintaining Crohn's disease in remission have significantly improved, most of the currently available modalities are associated with significant morbidity. Recently, an enteric-coated preparation of fish oil has been shown to be effective in reducing the rate of relapse in patients with Crohn's disease in remission who are at high risk of relapse. Because of minimal side effects, fish oil appears to be an ideal maintenance agent in Crohn's disease. However, until results from studies that compare the therapeutic effect of fish oil to the currently available maintenance agents are available, fish oil supplementation cannot be recommended as a sole maintenance agent at present. It does, however, seem prudent to promote a diet rich in fish oil in patients with Crohn's disease.
管理克罗恩病最大的挑战之一是维持缓解状态。尽管维持克罗恩病缓解的药物治疗方法已有显著改善，但目前大多数可用的治疗方式都伴有明显的发病率。最近，一种肠溶包衣的鱼油制剂已被证明可有效降低处于缓解期但复发风险高的克罗恩病患者的复发率。由于副作用极小，鱼油似乎是克罗恩病理想的维持治疗药物。然而，在有研究比较鱼油与现有维持治疗药物的治疗效果之前，目前不能推荐单独使用鱼油补充剂作为维持治疗药物。不过，建议克罗恩病患者采用富含鱼油的饮食似乎是明智的。
