[Studies on human immunoglobulin preparations: II. Purity and composition (author's transl)].

16 human immunoglobulin preparations for intravenous and/or intramuscular use of 4 different manufacturers were tested with regard to their purity and composition. Anticomplementary activity was detected in preparations for i.m. application, but surprisingly also in some preparations for intravenous use, a fact which may possibly cause allergic or anaphylactic reactions. Besides IgG, which accounted for the main part of the protein content, small amounts of IgA, IgD, and IgM were found. IgE was detected in every batch studied. Some contained IgE-concentrations, usually seen in atopic persons.