Zach M, Beitzke A, Grubbauer H M
Padiatr Padol. 1977;12(3):245-57.
Life-threatening, glycoside-induced cardiac rhythm disturbances are often seen following accidental digitalis intoxication in small children. Modern therapeutic management should take into consideration the pharmacokinetics as well as the mechanisms responsible for cardiac and extracardiac symptoms. Discussed are the possibilities of eliminating and inactivating the ingested glycosides, the indications and contraindications for administration of electrolytes, as well as the use of anti-arrhythmic drugs and pacing for cardiac arrhythmias. Special consideration should be given to close observation and instrumental monitoring; ideally these should be carried out in an intensive care unit. Unnecessary loss of time in the management of such cases should be avoided through proper organization of diagnostic and therapeutic activities.
危及生命的洋地黄苷诱导的心律失常常见于小儿意外洋地黄中毒后。现代治疗管理应考虑药代动力学以及导致心脏和心脏外症状的机制。讨论了消除和灭活摄入的洋地黄苷的可能性、电解质给药的适应证和禁忌证,以及抗心律失常药物的使用和心律失常的起搏治疗。应特别重视密切观察和仪器监测;理想情况下,这些应在重症监护病房进行。通过合理组织诊断和治疗活动,应避免在此类病例管理中不必要的时间浪费。