1型孔蛋白通道（电压依赖性阴离子通道）在肌浆网中的定位。
Localization of type-1 porin channel (VDAC) in the sarcoplasmatic reticulum.
作者信息
Jürgens L, Kleineke J, Brdiczka D, Thinnes F P, Hilschmann N
机构信息
Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany.
出版信息
Biol Chem Hoppe Seyler. 1995 Nov;376(11):685-9.
Eucaryotic porin channels or voltage-dependent anion channels (VDACs) are expressed in the outer mitochondrial membranes and in the plasmalemma of mammalian cells. Subfractions of sarcoplasmatic reticulum (SR) obtained from rabbit skeletal muscle display type-1 porin channels in transverse tubuli (TT) when analysed by immunoblot analysis with type-1 porin specific monoclonal antibodies. These data are in agreement with our recent proposal suggesting the presence of porin channels in non-mitochondrial eucaryotic membranes.
真核孔蛋白通道或电压依赖性阴离子通道（VDACs）在哺乳动物细胞的线粒体外膜和质膜中表达。当用1型孔蛋白特异性单克隆抗体进行免疫印迹分析时，从兔骨骼肌获得的肌浆网（SR）亚组分在横小管（TT）中显示出1型孔蛋白通道。这些数据与我们最近提出的关于非线粒体真核细胞膜中存在孔蛋白通道的提议一致。
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