Chang F Y, Lee S D, Yeh G H, Wang P S
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, Republic of China.
J Gastroenterol Hepatol. 1995 Sep-Oct;10(5):585-8. doi: 10.1111/j.1440-1746.1995.tb01350.x.
Orogastric feeding of a charcoal meal to rats was employed to measure whether the various stages of pregnancy could influence gastrointestinal transit. The oestrous cycle of female Sprague-Dawley rats was checked daily. If pro-oestrus occurred, the first day of pregnancy was defined to be on the next day after the copulation. Gastrointestinal transit studies were conducted on day 7 (first trimester), day 14 (second) and day 21 (third), respectively. The rats were killed 15 min after the successful feeding of a calorie-free, charcoal-containing test meal via a transiently placed orogastric catheter. Gastrointestinal transit was defined as the per cent of charcoal transit divided by the total length of the small intestine. These results were compared with the data obtained from non-pregnant female rats. Mean percentages of transit for the first, second and third trimester, and for controls were 42.8 +/- 1.9, 45.3 +/- 4.1, 35.7 +/- 1.7 and 42.6 +/- 1.4%, respectively (mean +/- s.e.). Late pregnancy elicited a marked inhibition of transit (P < 0.01). A significant negative correlation between transit and uterine weight of all pregnant rats was seen (r = -0.50, P < 0.05). The present study indicates that inhibited gastrointestinal transit occurs in the late pregnant rat.
通过给大鼠经口胃内喂食炭末餐来测定孕期各阶段是否会影响胃肠运输。每天检查雌性斯普拉格-道利大鼠的发情周期。若出现动情前期，则将交配后次日定义为妊娠第1天。分别在妊娠第7天（孕早期）、第14天（孕中期）和第21天（孕晚期）进行胃肠运输研究。经临时放置的口胃导管成功喂食不含热量、含炭末的试验餐后15分钟，处死大鼠。胃肠运输定义为炭末运输的百分比除以小肠总长度。将这些结果与非妊娠雌性大鼠的数据进行比较。孕早期、孕中期、孕晚期及对照组的平均运输百分比分别为42.8±1.9%、45.3±4.1%、35.7±1.7%和42.6±1.4%（平均值±标准误）。妊娠后期引起运输显著抑制（P<0.01）。观察到所有妊娠大鼠的运输与子宫重量之间存在显著负相关（r=-0.50，P<0.05）。本研究表明，妊娠后期大鼠胃肠运输受到抑制。
