Reuber M D
Neoplasma. 1979;26(2):231-5.
Young male and female albino rats ingested 0, 1, 5, 10 or 25 ppm Kepone, an organochlorine pesticide, in the diet for two years. Carcinomas of the liver, as well as hyperplastic nodules and moderate and severe diffuse hyperplasia were observed in Kepone-treated rats. Such hepatic lesions were not seen in control rats. Female rats ingesting Kepone were more susceptible than male rats to hepatic carcinogenesis. Rats ingesting 50 or 80 ppm Kepone developed severe diffuse hepatic hyperplasia and did not survive beyond 26 weeks.
年轻的雄性和雌性白化病大鼠在两年的时间里，在饮食中摄入了0、1、5、10或25 ppm的开蓬（一种有机氯农药）。在接受开蓬处理的大鼠中观察到了肝癌，以及增生性结节和中度及重度弥漫性增生。在对照大鼠中未发现此类肝脏病变。摄入开蓬的雌性大鼠比雄性大鼠对肝脏致癌作用更敏感。摄入50或80 ppm开蓬的大鼠出现了严重的弥漫性肝脏增生，并且在26周内死亡。
