David E, Andronescu D, Serban D, Cocean S
Centrul Medical de Servicii de Sănătate şi Conducere Cluj-Napoca.
Bacteriol Virusol Parazitol Epidemiol. 1996 Jan-Jun;41(1-2):43-6.
The sensitivity of 59 Salmonella strains isolated in children with acute diarrhoea was tested against the new quinolones like: Ciproflaxicin (CIP), Norfloxacin (NOR) and Ofloxacin (OFX), as compared to the sensitivity against same aminosides: Gentamicin (GM), Amikacin (AN) against cephalosporins: Ceftazidime (CAZ), Cefalotine (CF) and other currently used antimicrobial agents: Tetraciclin (T), Ampicilin (A), Cloramfenicol (C), Furazolidon (FU). The majority of the studied Salmonella strains, 43 out of 59 strains, belonged to the serotype typhimurium, the most frequently serotype isolated in our geographical area. A very high percentage of Salmonella strains were sensitive against the three quinolones: 98,30% sensitive against NOR, 91,5% sensitive against OFX, 91,50% sensitive against CIP and 96,6% sensitive against AN. In contrast, the Salmonella strains sensitivity was lower in the other tested antimicrobial substances: C (32,2% sensitive strains), GM (8,5%), A (16,9%), CF (11,9%), T (3,4%), FU (1,7%). Out of 59 strains, 45 where resistant to more than four antibiotics, the most often observed pattern was: A, CAZ, CF, GM, T, C, FU.
对从急性腹泻儿童中分离出的59株沙门氏菌菌株，测试了其对新型喹诺酮类药物如环丙沙星（CIP）、诺氟沙星（NOR）和氧氟沙星（OFX）的敏感性，并与它们对相同氨基糖苷类药物庆大霉素（GM）、阿米卡星（AN）、头孢菌素类药物头孢他啶（CAZ）、头孢噻吩（CF）以及其他目前使用的抗菌药物四环素（T）、氨苄西林（A）、氯霉素（C）、呋喃唑酮（FU）的敏感性进行比较。在所研究的沙门氏菌菌株中，59株中有43株属于鼠伤寒血清型，这是在我们所在地理区域分离出的最常见血清型。沙门氏菌菌株对三种喹诺酮类药物的敏感性非常高：对NOR敏感的占98.30%，对OFX敏感的占91.5%，对CIP敏感的占91.50%，对AN敏感的占96.6%。相比之下，沙门氏菌菌株对其他测试抗菌物质的敏感性较低：对C敏感的菌株占32.2%，对GM敏感的占8.5%，对A敏感的占16.9%，对CF敏感的占11.9%，对T敏感的占3.4%，对FU敏感的占1.7%。在59株菌株中，有45株对四种以上抗生素耐药，最常观察到的耐药模式是：A、CAZ、CF、GM、T、C、FU。
