Peters E T, Seidell J C, Menotti A, Arayanis C, Dontas A, Fidanza F, Karvonen M, Nedeljkovic S, Nissinen A, Buzina R
Department of Chronic Disease and Environmental Epidemiology, National Institute of Public Health and Environmental Epidemiology, Bilthoven, Netherlands.
Int J Obes Relat Metab Disord. 1995 Dec;19(12):862-8.
To study the relation between changes in body weight and subsequent mortality.
Prospective follow-up study.
Population study.
6441 men aged 40-59 y at baseline participating in the European cohorts of the Seven Countries Study. The men were divided into groups depending on their weight pattern ascertained from three weight measurements with intervals of 5 years. They were also divided in quartiles according to the degree of weight variability.
All-cause and cause-specific mortality during 15 years following the last weight measurement. Deaths occurring during the first 5 years of follow-up were excluded.
Significantly elevated hazard ratios (RR) for death from all causes (RR = 1.3; 95% confidence interval (CI): 1.2-1.5), all cardiovascular diseases (RR = 1.2; 95% CI: 1.0-1.5) and other causes (RR = 1.6; 95% CI: 1.2-2.2) were found for men with a decreasing weight compared with men with a constant weight. A fluctuating weight was associated with an increased risk of all cause mortality (RR = 1.2; 95% CI: 1.0-1.4), coronary heart disease (RR = 1.5; 95% CI: 1.0-1.9) and myocardial infarction (RR = 1.5; 95% CI: 1.0-2.2). The group of men with an increasing body weight also had elevated hazard ratios for dying from coronary heart disease and myocardial infarction, but these were only significant when the total 15-year follow-up was analyzed. The risks of dying from all-causes, cardiovascular disease, cancer and other causes were increased in the upper quartile versus the lower quartile of weight variability.
The results of the present study show that a decreasing and a fluctuating body weight are associated with increased mortality. An average increase of 7 kg body weight was associated with an elevated risk of dying from coronary heart disease and myocardial infarction. Lowest mortality in these middle-aged men was found in those who maintained a constant body weight.
研究体重变化与随后死亡率之间的关系。
前瞻性随访研究。
人群研究。
6441名年龄在40 - 59岁之间的男性，他们在基线时参与了七国研究的欧洲队列。根据间隔5年的三次体重测量确定的体重模式，将这些男性分为不同组。他们还根据体重变化程度分为四分位数。
最后一次体重测量后15年内的全因死亡率和特定病因死亡率。随访前5年发生的死亡被排除。
与体重恒定的男性相比，体重下降的男性全因死亡（风险比（RR）= 1.3；95%置信区间（CI）：1.2 - 1.5）、所有心血管疾病死亡（RR = 1.2；95% CI：1.0 - 1.5）和其他原因死亡（RR = 1.6；95% CI：1.2 - 2.2）的风险比显著升高。体重波动与全因死亡率增加（RR = 1.2；95% CI：1.0 - 1.4）、冠心病（RR = 1.5；95% CI：1.0 - 1.9）和心肌梗死（RR = 1.5；95% CI：1.0 - 2.2）风险增加相关。体重增加的男性组死于冠心病和心肌梗死的风险比也升高，但仅在分析整个15年随访期时才具有统计学意义。体重变化上四分位数组与下四分位数组相比，全因、心血管疾病、癌症和其他原因死亡风险增加。
本研究结果表明，体重下降和体重波动与死亡率增加相关。体重平均增加7 kg与死于冠心病和心肌梗死的风险升高相关。在这些中年男性中维持恒定体重者死亡率最低。
