Chobitko V G, Zakharova N B
Klin Lab Diagn. 1993 May-Jun(3):15-7.
The authors describe a method for the prediction of the therapeutic effect of energy-stabilizing drugs, that helps rapidly select the optimal individual therapeutic policy. The method is based on measurement of the red cell ATP concentration in the course of in vitro incubation of cells in polyionic medium with the drug, and may be used in various diseases associated with energy metabolism disorders on the cellular level. The authors have used this method for the selection of a thiamine drug to be included in therapy of a diabetic in the period of the disease compensation.
作者描述了一种预测能量稳定药物治疗效果的方法，该方法有助于快速选择最佳的个体化治疗策略。该方法基于在含有药物的聚离子介质中对细胞进行体外培养过程中红细胞ATP浓度的测量，可用于与细胞水平能量代谢紊乱相关的各种疾病。作者已使用该方法为一名处于疾病代偿期的糖尿病患者选择治疗中使用的硫胺类药物。
